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David Leffell
David J. Leffell, MD, was born in 1956 in Montreal, Canada and educated at Yale. Leffell is an internationally recognized expert in skin cancer and the Mohs technique, plastic reconstruction, and new technologies in dermatology. He specializes in the diagnosis, treatment, and prevention of melanoma and nonmelanoma skin cancer.〔http://www.yalecancercenter.org/answers/download/pdf/Answers_July_1_07.pdf〕 He is the David Paige Smith Professor of Dermatology and Surgery,〔http://dermatology.yale.edu/faculty/leffell.html〕 chief of Dermatologic Surgery and Cutaneous Oncology, and former Deputy Dean for Clinical Affairs at Yale University School of Medicine (). In January 2012, Dr. Leffell stepped down as chief executive officer of the Yale Medical Group (), after 15 years of leadership of the organization. He serves on the board of (Validus Pharmaceuticals ) and is a trustee of ( The Hopkins School ), one of America's oldest independent schools.
==Research==
While still in medical training, Leffell developed and patented a laser method for measuring the aging of skin.〔http://www.google.com/patents?id=kUM5AAAAEBAJ&dq=david+leffell〕 With Douglas Brash and others he has also published work that clarifies the genetic basis of the cancer-causing ultraviolet rays of the sun. This work represented proof that an environmental agent could directly be linked to a genetic injury that causes cancer . Leffell was a member of the international team that discovered PTC1, a tumor suppressor gene that plays a critical role in the development of hereditary and sporadic basal cell cancer. He shares patents for the PTC gene〔http://www.google.com/patents?id=ckAOAAAAEBAJ&dq=david+leffell〕 and PTCH protein.〔http://www.google.com/patents?id=joCpAAAAEBAJ&dq=david+leffell〕 In 2012, GenentechRoche introduced an oral medication based on the related hedgehog pathway 〔http://www.erivedge.com/index.html?cid=erv_pa_F001185_P000453&moc=MBEVUA1012&utm_source=bing&utm_medium=cpc&utm_term=vismodegib&utm_campaign=Bing%202012%20Erivedge%20Branded%20RAIS-2%20(Jun12)〕 Leffell also invented a simple office-based method for the (treatment of vitiligo ), a depigmenting disorder for which treatment is otherwise limited. In collaboration with (Susan Mayne, PhD ) at the Yale School of Public Health, Leffell has researched the role of tanning parlors in the development of skin cancer in young women.〔Ferrucci, L. M., Cartmel, B., Molinaro, A. M., Leffell, D. J., Bale, A. E., and Mayne, S. T. Indoor tanning and risk of early-onset basal cell carcinoma. J. Am. Acad. Dermatol. 8 December 2011, doi: 10.1016/j.jaad.2011.11.940. NIHMS339428.〕
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